If you’ve ever wondered why some people with herpes rarely have outbreaks while others deal with them regularly, you’re not alone. This difference isn’t about luck or personal hygiene—it’s rooted in biology, and much of it comes down to how your immune system interacts with the herpes virus.
After the initial infection, herpes simplex virus (HSV) settles into a long-term relationship with your body, lying dormant in the nervous system. Whether or not it stays quiet—or flares up—largely depends on how well your immune system keeps it in check. While some people’s bodies are able to suppress the virus effectively, others may experience more frequent or intense reactivations.
This variation is influenced by a mix of genetics, immune function, and even small differences in how much virus is released during reactivation. For instance, certain genetic traits may make it harder for your immune system to recognize or control HSV. Others may have subtle immune imbalances that affect how their body responds when the virus tries to resurface.
Understanding this relationship between immune health and herpes doesn’t just explain why outbreaks happen—it also points toward what you can do to reduce their impact. By learning how your body manages the virus and what factors might be making it harder, you can start taking steps that support your immune system and help reduce the risk of flare-ups.
How Your Immune System Keeps Herpes in Check
After the first encounter with herpes simplex virus (HSV), the virus doesn’t leave your body—it hides. Rather than continuing to cause symptoms, it retreats into the nervous system, finding a long-term home in nerve clusters called ganglia. In these quiet spaces, like the trigeminal or sacral ganglia, the virus enters a latent state. It stops actively multiplying and instead lingers as a strand of DNA, tucked away inside your sensory neurons.
What allows HSV to stay hidden is a combination of clever viral tactics and the unique nature of the nervous system. Neurons are less likely to provoke a full-force immune response, making them a relatively safe space for the virus to rest. During latency, HSV produces special molecules—called latency-associated transcripts—that help it avoid immune detection and prevent reactivation.
But the immune system doesn’t just forget it’s there.
Specialized immune cells, particularly T-cells, act as vigilant sentinels. CD8+ tissue-resident memory T-cells patrol the ganglia, ready to respond if HSV begins to stir. They do this by releasing signals like interferon-Îł and other molecules that can stop the virus from replicating. CD4+ T-cells also play a supporting role, producing helpful cytokines that boost the activity of their CD8+ counterparts.
This balance can be surprisingly delicate. When your immune system is temporarily weakened—by stress, illness, medication, or even injury—its surveillance can slip. That’s when HSV may seize the opportunity to reactivate, moving from the nerves back to the skin or mucous membranes and causing an outbreak.
Importantly, immunity isn’t just a matter of being “strong” or “weak.” It’s more like an orchestra—complex, dynamic, and highly responsive to your environment. Your susceptibility to outbreaks may be shaped by subtle immune differences, your body’s ability to recognize and regulate inflammation, and even your genetic profile. For some, immune control is consistently tight. For others, certain triggers can loosen that grip.
Understanding this immune dance offers more than just scientific insight—it gives you a clearer picture of why outbreaks might happen and what’s within your control to help reduce them.
Why Some People Get More Herpes Outbreaks Than Others
Herpes doesn’t behave the same way in every body—and that can be incredibly frustrating for people trying to make sense of their own pattern of symptoms. One person may go months or even years without an outbreak, while another might deal with recurrences regularly. The reasons for this difference run deeper than surface-level health and often start at the immune level.
Your Immune Response Plays a Big Role
Our immune systems aren’t identical. From birth, each person inherits a unique set of genes that influence how the body responds to viruses like HSV. These genetic differences can shape how well the immune system controls reactivation. Some people generate strong, fast T-cell responses—especially from CD8+ cells that are key to keeping HSV in check. Others may have immune pathways that respond more slowly or less effectively.
There’s also variability in how people produce interferons, the signaling proteins that help suppress viral replication. Even small differences here can impact how often herpes reactivates.
Chronic Conditions Can Tip the Balance
Underlying health issues can quietly lower your defenses. Conditions that affect the immune system—like HIV, diabetes, or autoimmune diseases—can make it harder to suppress HSV. In these cases, the immune cells responsible for surveillance and response may not work as well, leaving the virus more room to reactivate.
Some treatments for chronic illness, such as immunosuppressive medications, also contribute to this vulnerability. They reduce inflammation but may also reduce the body’s ability to prevent viral reactivation.
Lifestyle Factors That Influence Immunity
Daily habits matter, too. Long-term stress, poor sleep, nutritional gaps, or even smoking can all interfere with how well your immune system performs. For example, chronic stress affects the balance of signaling molecules called cytokines, weakening your frontline defenses. Nutrient deficiencies can reduce your body’s ability to produce interferons and other protective agents. And excessive exercise—while healthy in moderation—can actually impair immune function when it becomes extreme or unrelenting.
Illness and Injury as Temporary Triggers
Sometimes the immune system is simply distracted. If you’re recovering from a cold, flu, surgery, or even a small injury, your body may be too focused on healing to keep HSV fully contained. This temporary lapse can be enough to allow the virus to reactivate and travel back to the surface, causing an outbreak.
Hormones Add Another Layer
In many people, hormonal changes—particularly those tied to the menstrual cycle, hormonal contraceptives, or perimenopause—can affect immune regulation. Estrogen and other hormones help maintain mucosal defenses, so shifts in hormone levels may make it easier for HSV to flare. This is why some people notice outbreaks that seem tied to certain times of the month or phases of life.
Signs Your Immune System May Be Overwhelmed
Herpes outbreaks can sometimes feel like a barometer for your body’s internal state. When your immune system is under pressure—whether from illness, stress, or everyday wear and tear—you may notice changes not just in your herpes symptoms, but in how your whole body feels. While occasional outbreaks are part of living with the virus, certain patterns may suggest your immune system could use more support.
Frequent or Severe Outbreaks
If you’re experiencing frequent or unusually intense outbreaks, it might be a sign that your immune defenses aren’t fully holding the virus in check. Research shows that when certain immune cells, like dendritic cells and T-cells, aren’t functioning optimally, HSV can more easily reactivate. This doesn’t mean your immune system is failing—it just means it may be stretched thin or out of balance. Inflammation that isn’t well-regulated can also contribute to more noticeable or stubborn symptoms.
Slow Healing Times
Healing is a team effort between your skin and your immune system. When that process takes longer than usual—such as with cold sores or genital lesions that linger—it could indicate that the immune response is struggling. Some of this delay may be due to how HSV interferes with immune signaling, including reducing interferon production or disrupting the function of cells that coordinate healing. If you notice that outbreaks are not just frequent but also slow to resolve, that’s worth paying attention to.
Getting Sick Often or Feeling Chronically Rundown
Beyond herpes itself, frequent colds, infections, or a lingering sense of fatigue can suggest that your immune system is carrying more than it can manage. HSV doesn’t just stay in one part of the body—it can have subtle, system-wide effects. Chronic immune activation from recurrent viral activity may leave you more vulnerable to other bugs, and can also sap your energy over time. Feeling consistently drained might be your body’s way of signaling that it’s time to recalibrate.
Difficulty Bouncing Back from Stress
Stress doesn’t just affect your mood—it reshapes your immune function. When your system is healthy and responsive, it can recover quickly after a period of emotional or physical stress. But if you find yourself dragging for days or weeks after an argument, illness, or busy period, your immune system may be stuck in a low-resilience mode. HSV is known to take advantage of these windows, slipping past immune defenses when they’re distracted or depleted. The virus can also worsen the effects of stress, creating a feedback loop that’s hard to break without rest and recovery.
Strengthening Your Immunity to Reduce Herpes Outbreaks
While there’s no way to eliminate the herpes virus once it’s in the body, there’s a lot you can do to support your immune system and reduce the likelihood of outbreaks. Because HSV takes advantage of immune vulnerability, building habits that strengthen your overall immunity can make a real difference in how often—and how severely—you experience symptoms.
Sleep: Your Body’s Reset Button
Getting 7 to 9 hours of quality sleep isn’t just about feeling rested—it’s fundamental to immune function. Sleep is when your body restores and regulates key components of your immune system, including natural killer cells and interferon responses that help suppress viral reactivation. When sleep is cut short or disrupted, inflammation rises and the body’s defenses dip, making it easier for HSV to break through its usual containment.
Fueling Immunity with Nutrition
The foods you eat can either support or strain your immune system. Nutrients like zinc, vitamin C, and antioxidants play critical roles in helping immune cells function properly. Lysine—an amino acid found in protein-rich foods or taken as a supplement—has also been studied for its potential to interfere with HSV replication by competing with arginine, another amino acid the virus relies on. A well-balanced, nutrient-dense diet creates the internal environment your immune system needs to stay vigilant.
The Power of Movement—Without Overdoing It
Regular, moderate physical activity boosts the circulation of immune cells throughout your body, improving your ability to detect and control viruses like HSV. But more isn’t always better. Overtraining or skipping rest days can lead to elevated stress hormones and short-term dips in immune function. If you’re staying active, aim for consistency over intensity, and listen to your body’s cues for recovery.
Managing Stress for Immune Stability
Chronic stress is one of the most common triggers for herpes outbreaks, in part because of how it disrupts immune regulation. High cortisol levels—your body’s main stress hormone—can suppress the very cells needed to keep HSV dormant. Mindfulness practices, therapy, journaling, or simply creating moments of calm in your day can reduce the physiological burden of stress. Not only does this help you feel better emotionally, it also gives your immune system more capacity to do its job.
Gut Health Matters More Than You Think
The gut is deeply connected to the immune system, and taking care of your digestive health can have ripple effects on your body’s ability to control HSV. A diverse, fiber-rich diet feeds the beneficial bacteria that produce compounds supporting immune balance. Probiotics may also help strengthen your gut barrier and promote regulatory T-cell activity, adding another layer of defense against viral reactivation.
Medical and Supplement Support Options
Sometimes lifestyle changes alone aren’t enough to fully manage herpes outbreaks—and that’s okay. Medical therapies and targeted supplements can offer meaningful support by working alongside your body’s immune system to reduce the virus’s ability to reactivate. For many people, a thoughtful combination of daily habits and medical interventions is what makes the biggest difference.
Suppressive Antiviral Therapy
For those who experience frequent or severe outbreaks, daily antiviral medication can be a game-changer. Suppressive therapy with drugs like acyclovir or valacyclovir helps reduce how often the virus becomes active—and how much virus is present when it does. Research shows that consistent use of these medications can cut HSV shedding by up to 80%, giving the immune system more breathing room to keep the virus contained.
Suppressive therapy doesn’t just reduce outbreaks—it also lowers the risk of passing the virus to partners during asymptomatic periods. And while traditional antivirals remain the mainstay, newer developments—like adoptive T-cell therapies aimed at helping the immune system better recognize and neutralize HSV—are showing promise, particularly for people with compromised immunity.
Targeted Supplements: Lysine, Zinc, and Vitamin D
Certain nutrients may offer added protection when used thoughtfully. Lysine, for example, may help reduce the frequency of outbreaks by limiting the availability of arginine, an amino acid HSV needs to replicate. Some people find that taking lysine daily—especially when combined with a lower-arginine diet—can help maintain longer periods of remission.
Zinc also plays a critical role in antiviral defense. It not only supports immune cell function but may interfere with the virus’s ability to replicate. Likewise, vitamin D helps regulate immune responses, and low levels have been linked to an increased risk of various viral infections, including herpes. If you’re considering any of these supplements, it’s best to speak with a healthcare provider about dosing and safety based on your individual needs.
When to Consider Bloodwork or Further Testing
If you’re doing everything you can and still experiencing frequent or difficult outbreaks, it might be time to dig a little deeper. Blood tests to check vitamin D or zinc levels can uncover nutritional deficiencies that are impacting your immune resilience. Autoimmune screening may also be appropriate if there are signs of broader immune system dysregulation.
Your healthcare provider can help tailor a plan based on these insights—whether that’s adjusting your medication, adding targeted supplements, or exploring other therapies. Personalized support often makes a noticeable difference in how your body manages HSV long-term.
What If You’re Doing Everything “Right” and Still Get Outbreaks?
One of the most frustrating things about herpes is how it can still flare up even when you’re taking great care of your body. You might be sleeping well, eating balanced meals, managing stress, and staying consistent with your routine—and yet, an outbreak still appears. This isn’t a sign that you’re doing something wrong. It’s a reminder of how complex this virus really is.
Herpes Is Chronic—and Reactivation Happens
Once HSV enters your body, it stays for life, settling into nerve cells where it remains dormant. Even with a well-functioning immune system, the virus can occasionally reactivate. This is part of its nature. Certain internal shifts—like minor illnesses, hormone fluctuations, or even weather changes—can tip the balance just enough to allow the virus to surface.
Research also shows that stress hormones like epinephrine can activate HSV within autonomic neurons, regardless of how well your daily stress is managed. In other words, outbreaks can happen even when you’re doing your best.
Focus on Resilience, Not Perfection
Instead of aiming to eliminate outbreaks entirely, a more compassionate and effective approach is to focus on building resilience. Resilience means your body can recover quickly, manage symptoms effectively, and return to balance sooner. That might mean fewer outbreaks over time, shorter healing periods, or milder symptoms.
It also means allowing space for imperfection. Living with HSV doesn’t require you to be flawless—it asks for flexibility, awareness, and care. Emotional resilience is just as important as physical; being kind to yourself during an outbreak can reduce stress and support your body’s recovery process.
Use Timing to Your Advantage
If you’ve begun to notice patterns in when your outbreaks occur—around your period, during times of high pressure, after travel—you’re not imagining it. HSV reactivation often follows predictable rhythms, and leaning into that knowledge gives you a valuable tool.
You might choose to increase lysine supplementation during those high-risk windows, or prioritize extra rest and calming routines before stressful events. Keeping a personal symptom journal can help you identify your own triggers and plan around them. Small, proactive choices can go a long way in preventing or softening outbreaks.
Remember, managing herpes is not about achieving perfect control—it’s about supporting your body and mind in sustainable, informed ways.
When to Talk to a Healthcare Provider
Herpes may be a manageable condition, but that doesn’t mean you have to navigate it entirely on your own. If outbreaks start to feel disruptive, unusually painful, or just different from your norm, it may be time to bring in medical guidance. A healthcare provider can help you fine-tune your approach, identify underlying issues, and offer tools that go beyond what lifestyle changes alone can address.
If Outbreaks Are Frequent, Painful, or Slow to Heal
Recurring outbreaks—especially six or more in a year—could be a sign that your immune system needs more support. In these cases, daily antiviral therapy, like acyclovir or valacyclovir, can make a substantial difference, reducing the frequency and severity of episodes.
Outbreaks that are particularly painful or take longer than usual to heal might indicate complications or co-infections. Prolonged symptoms could also suggest antiviral resistance or an undiagnosed immune concern. If something feels off or your healing process seems stuck, a provider can help rule out these possibilities and adjust your care plan accordingly.
If You’re Immunocompromised or Living with a Chronic Condition
People with weakened immune systems—due to conditions like HIV, diabetes, or cancer treatment—face a higher risk of more serious HSV complications. In these cases, standard outbreak strategies may not be enough. You might need more proactive antiviral use or closer monitoring to avoid systemic complications.
Tailored care for HSV is especially important if you’re managing other chronic illnesses. Some health systems now recommend specialized treatment protocols for patients with underlying conditions, to ensure herpes doesn’t compromise overall wellness.
To Review Medications, Supplements, or Testing Options
If you’re using supplements like lysine or zinc—or thinking about starting—your provider can help you determine the right dose and assess whether they’re likely to help based on your health profile. Similarly, routine bloodwork can uncover hidden deficiencies, such as low vitamin D or zinc levels, that may be making your immune system less efficient at controlling HSV.
Your provider may also help you explore personalized prevention strategies, like syncing antiviral use with known triggers (e.g., menstrual cycles, stress periods, or travel). These small adjustments, made with medical insight, can add up to better long-term control.
You deserve care that supports not just the physical aspects of herpes, but the emotional and practical ones, too. A conversation with your provider can be an empowering step forward.
Learning to Work With Your Body
Living with herpes doesn’t mean fighting a constant battle—it means learning how your body responds, what throws it off balance, and how to support it through those moments. Your immune system plays a powerful, ongoing role in managing the virus, and the more you understand its rhythms, the more you can care for yourself with clarity and compassion.
Some outbreaks may still happen, even when you’re doing everything “right.” That’s not a failure—it’s part of living with a virus that’s deeply intertwined with your nervous and immune systems. What matters most is building habits that nurture resilience, paying attention to what your body needs, and reaching out for support when things feel out of sync.
There’s no one-size-fits-all formula, but there are plenty of tools—and you don’t have to figure them out alone. For more articles like this one, new insights, and resources to help you take care of your whole self, consider joining our mailing list. We’ll be here to support you, every step of the way.
References
Amin, I., Younas, S., Afzal, S., Shahid, M., & Idrees, M. (2019). Herpes Simplex Virus Type 1 and Host Antiviral Immune Responses: An Update. Viral Immunology.
Bloom, D., & Dhummakupt, A. (2016). The Herpes Simplex Viruses. In Neurotropic Viral Infections (pp. 111–134).
Carter, C., Savic, S., Cole, J., & Wood, P. (2007). Natural killer cell receptor expression in patients with severe and recurrent Herpes simplex virus-1 (HSV-1) infections. Cellular Immunology, 246(2), 65–74.
Chan, T. T., Barra, N., Lee, A. J., & Ashkar, A. (2011). Innate and adaptive immunity against herpes simplex virus type 2 in the genital mucosa. Journal of Reproductive Immunology, 88(2), 210–218.
Chavan, G. S., & Khaire, R. D. (2023). Herpes simplex virus infection. International Journal of Technology.
Clarke, E., Patel, R., Dickins, D., Fidler, K., Jackson, A., Kingston, M., Jones, C., Lyall, H., Nicholson, M., Pelosi, E., Porter, D., Powell, G., & Foley, E. (2024). Joint British Association for Sexual Health and HIV and Royal College of Obstetricians and Gynaecologists national UK guideline for the management of herpes simplex virus (HSV) in pregnancy and the neonate (2024 update). International Journal of STD & AIDS.
Conrady, C. D., Drevets, D., & Carr, D. J. J. (2010). Herpes simplex type I (HSV-1) infection of the nervous system: Is an immune response a good thing? Journal of Neuroimmunology, 220(1-2), 1–9.
Desai, D. V., & Kulkarni, S. S. (2015). Herpes Simplex Virus: The Interplay Between HSV, Host, and HIV-1. Viral immunology, 28(10), 546–555.
Duerst, R. J., & Morrison, L. A. (2003). Innate immunity to herpes simplex virus type 2. Viral immunology, 16(4), 475–490.
Egan, K. P., Wu, S., Wigdahl, B., & Jennings, S. R. (2013). Immunological control of herpes simplex virus infections. Journal of neurovirology, 19(4), 328–345.
FarĂas, M., Duarte, L. F., Tognarelli, E. I., & González, P. A. (2021). Herpes simplex virus interference with immunity: Focus on dendritic cells. Virulence, 12, 2583–2607.
Fatahzadeh, M., & Schwartz, R. (2007). Human herpes simplex virus infections: Epidemiology, pathogenesis, symptomatology, diagnosis, and management. Journal of the American Academy of Dermatology, 57(5), 737-763.Â
Hapid, M. H., & Setiadhi, R. (2022). A review: Zinc as an antivirus alternative treatment for herpes simplex virus infection. International Journal of Applied Pharmaceutics.
Hobbs, M., Jones, B., Otterud, B., Leppert, M., & Kriesel, J. (2008). Identification of a herpes simplex labialis susceptibility region on human chromosome 21. The Journal of Infectious Diseases, 197(3), 340–346.
Ike, A., Onu, C., Ononugbo, C. M., Reward, E. E., & Muo, S. O. (2020). Immune Response to Herpes Simplex Virus Infection and Vaccine Development. Vaccines.
Ives, A. M., & Bertke, A. (2017). Stress hormones epinephrine and corticosterone selectively modulate HSV-1 and HSV-2 productive infections in adult sympathetic, but not sensory, neurons. Journal of Virology, 91.Â
Kuilya, S. (2024). Interferons during HSV-2 infection: Immune regulation. International Journal of Scientific Research in Engineering and Management.
Lan, J., Yang, Y., & Qi, R. (2016). Pathogenic features of herpes simplex virus and anti-herpes simplex virus immunity in human body. International Journal of Dermatology and Venereology.
Ma, C. K., Clancy, L., Deo, S., Blyth, E., Micklethwaite, K. P., & Gottlieb, D. J. (2017). Herpes simplex virus type 1 (HSV-1) specific T-cell generation from HLA-A1- and HLA-A2-positive donors for adoptive immunotherapy. Cytotherapy, 19(1), 107–118.
Mailoo, V., & Rampes, S. (2017). Lysine for Herpes Simplex Prophylaxis: A Review of the Evidence. Integrative Medicine, 16(3), 42–46.
Mark, K. E., Wald, A., Magaret, A. S., Selke, S., Olin, L., Huang, M. L., & Corey, L. (2008). Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults. The Journal of infectious diseases, 198(8), 1141–1149.
Motamedifar, M., Sarvari, J., Ebrahimpour, A., & Emami, A. (2015). Symptomatic reactivation of HSV infection correlates with decreased serum levels of TNF-α. Iranian Journal of Immunology, 12(1), 27–34.
Mustafa, M., Illzam, Em., Muniandy, Rk., Sharifah, A., Nang, M., & Ramesh, B. (2016). Herpes simplex virus infections: Pathophysiology and management. IOSR Journal of Dental and Medical Sciences, 15(7), 85-91.
Napoletani, G., Protto, V., Marcocci, M. E., Nencioni, L., Palamara, A. T., & De Chiara, G. (2021). Recurrent Herpes Simplex Virus Type 1 (HSV-1) Infection Modulates Neuronal Aging Marks in In Vitro and In Vivo Models. International journal of molecular sciences, 22(12), 6279.
Nasiri, S., Barat, T., Bidari-zerehpoosh, F., & Mozafari, N. (2020). Chronic non-healing ulcers as presenting sign of acquired immunodeficiency syndrome. Malaysian Family Physician, 15(2), 30–33.
Porteous, C., Bradley, J. A., Hamilton, D. N., Ledingham, I. M., Clements, G. B., & Robinson, C. G. (1984). Herpes simplex virus reactivation in surgical patients. Critical care medicine, 12(8), 626–628.
Rooney, J., Straus, S., Mannix, M., Wohlenberg, C., Alling, D., Dumois, J., & Notkins, A. (1993). Oral Acyclovir To Suppress Frequently Recurrent Herpes Labialis: A Double-Blind, Placebo-Controlled Trial. Annals of Internal Medicine, 118, 268–272.
Safrin, S., Ashley, R., Houlihan, C., Cusick, P. S., & Mills, J. (1991). Clinical and serologic features of herpes simplex virus infection in patients with AIDS. AIDS (London, England), 5(9), 1107–1110.
Schiffer, J. T., Abu-Raddad, L., Mark, K. E., Zhu, J., Selke, S., Magaret, A., Wald, A., & Corey, L. (2009). Frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model. Science translational medicine, 1(7), 7ra16.
St Leger, A. J., Koelle, D. M., Kinchington, P. R., & Verjans, G. M. G. M. (2021). Local Immune Control of Latent Herpes Simplex Virus Type 1 in Ganglia of Mice and Man. Frontiers in immunology, 12, 723809.
Stefanidou, M., Ramos, I., Mas Casullo, V., Trépanier, J. B., Rosenbaum, S., Fernandez-Sesma, A., & Herold, B. C. (2013). Herpes simplex virus 2 (HSV-2) prevents dendritic cell maturation, induces apoptosis, and triggers release of proinflammatory cytokines: potential links to HSV-HIV synergy. Journal of virology, 87(3), 1443–1453.
Steiner, I., & Tyler, K. L. (2014). The toll (like receptor 3) to the pathogenesis of herpes simplex encephalitis. Neurology, 83(21), 1882–1883.
Sullivan, B. A. (2015). Studies in the immune control of herpes simplex virus type 1 (HSV-1) latency: The role of CD4+ T cells and IL-10 in HSV-1 latency.
Suzich, J. B., & Cliffe, A. R. (2018). Strength in diversity: Understanding the pathways to herpes simplex virus reactivation. Virology, 522, 81–91.
Truong, N. R., Smith, J. B., Sandgren, K. J., & Cunningham, A. L. (2019). Mechanisms of Immune Control of Mucosal HSV Infection: A Guide to Rational Vaccine Design. Frontiers in immunology, 10, 373.
Ventura, A., Merajver, S., Shew, M., Kahn, J., DeKruyff, R., & Umetsu, D. (2013). HSV: herpes simplex virus Reactivation: HSV DNA in sensory ganglia neurons directs synthesis of mRNA molecules that encode proteins required for HSV DNA replication and assembly of daughter virions.
Vollmer-Conna, U., Chen, M., & Donovan, B. (2019). Regional but not systemic immune parameters relate to neuropsychiatric morbidity in patients with genital herpes simplex virus (HSV) infection. Brain, Behavior, and Immunity, 76.
Xu, X., Fan, S., Wang, X., Hu, Y., Feng, M., Wang, L., Zhang, Y., Liao, Y., Zhang, X., & Li, Q. (2017). Analysis of the Protective Immunity Induced by Herpes Simplex Virus 1 Strain M3 with an Attenuated Phenotype Due to Mutations in the Viral ul7, ul41, and LAT Genes. Frontiers in microbiology, 8, 1958.
Yan, C., Luo, Z., Li, W., Li, X., Dallmann, R., Kurihara, H., Li, Y.-F., & He, R. (2019). Disturbed Yin–Yang Balance: Stress Increases the Susceptibility to Primary and Recurrent Infections of Herpes Simplex Virus Type 1. Acta Pharmaceutica Sinica B, 10, 383–398.
Zhang, J., Liu, H., & Wei, B. (2017). Immune response of T cells during herpes simplex virus type 1 (HSV-1) infection. Journal of Zhejiang University. Science. B, 18(4), 277–288.
