For many, the words “herpes diagnosis” carry more weight than they should. Between misinformation, stigma, and the subtlety of symptoms, it’s easy to feel overwhelmed. But understanding how herpes is diagnosed—and why that matters—is a crucial step toward managing your health with clarity and confidence.
Accurate herpes diagnosis is more than just a label. It guides appropriate treatment, helps prevent complications, and supports informed decisions about relationships and sexual health. When someone receives a timely diagnosis, antiviral medication can be started early, which reduces both the severity of symptoms and the risk of transmitting the virus to others. For people who are pregnant, testing is especially important. Even without symptoms, HSV can be passed to a baby during childbirth, and preventive steps—like a C-section in certain cases—can protect the newborn from serious complications.
There’s also a deeper emotional value in knowing your status. Whether someone tests positive or negative, having clear information can lead to meaningful behavior changes, such as reduced number of partners or increased condom use. Just as importantly, accurate diagnosis can spare people the anxiety that comes from misdiagnosis or unclear results. False positives can carry a heavy emotional toll, and reliable testing helps reduce unnecessary stigma and distress.
Understanding the viruses themselves helps make sense of the process. Herpes simplex virus type 1 (HSV-1) most commonly causes cold sores around the mouth but can also lead to genital infections through oral-genital contact. HSV-2, on the other hand, primarily affects the genital area. Both viruses can lie dormant in the body and reactivate from time to time, often without warning. Stress, illness, or a weakened immune system can trigger an outbreak—even years after the initial infection.
Globally, herpes is incredibly common. HSV-2 alone affects roughly 12% of people in the U.S., and HSV-1 is even more widespread. Yet most people who carry the virus have no idea, because symptoms don’t always appear—or are so mild they go unnoticed. That’s part of what makes herpes so tricky. Around 80% of people with HSV-2 are unaware of their infection, and many transmissions happen when no symptoms are present.
On top of this, diagnostic challenges can cloud the picture. Not all herpes tests are equally accurate—especially when it comes to detecting HSV-1—leading to confusion, false results, and missed opportunities for treatment. Then there’s the stigma. Fear, shame, and isolation can delay testing, treatment, and even honest conversations with partners.
So when should someone consider getting tested? If you’re experiencing symptoms like genital sores or discomfort, have a partner with herpes, or are pregnant, testing is a valuable next step. It’s also recommended for people who are at higher risk, including those living with HIV, those with multiple sexual partners, or anyone diagnosed with another STI. Knowing your status can be empowering—and it’s one of the most responsible things you can do for your health and the wellbeing of others.
In this guide, we’ll explore how doctors test for herpes, what each test can (and can’t) tell you, and how timing, symptoms, and life circumstances shape the diagnostic process. Because getting answers shouldn’t be confusing—and it certainly shouldn’t be shameful.
The Clinical Evaluation
When someone comes in with possible symptoms of herpes, the diagnostic process often starts with a careful clinical evaluation. This first step is about more than just looking at the skin—it’s a thoughtful combination of observation, medical experience, and personal history that helps guide whether further testing is needed.
What doctors look for during a physical exam
Physicians begin by visually examining the external genital area, which includes the vulva or penis, the skin around the anus, and even the inner thighs. They’re looking for signs like redness, ulcers, or blisters—especially if symptoms are new or painful. If internal lesions are suspected but the patient is in discomfort, a speculum exam might be avoided to reduce pain.
In-office tests can also play a role at this stage. If ulcers are present, doctors may use a swab to collect a sample for laboratory testing—either PCR, which looks for the virus’s genetic material, or a culture test, which tries to grow the virus in a lab setting. Additional exams like a vaginal pH test or a quick “whiff” test may be done to rule out other common infections that can cause irritation or discharge, such as bacterial vaginosis or trichomoniasis.
In rare cases, particularly when symptoms are more severe or systemic, a broader physical exam may be necessary. Herpes can sometimes lead to neurological complications, like encephalitis, especially if it spreads to the brain. In such cases, doctors may assess for confusion, memory changes, or even subtle signs like one-sided goosebumps—an unusual but telling clue.
Visual signs doctors might notice
Genital herpes often begins with small, fluid-filled blisters that appear in clusters on a reddish base. These blisters usually burst within a day or two, leaving behind shallow, painful ulcers that can take a week or more to heal. Redness alone—especially around the labia or penis shaft—can be an early warning sign, particularly if accompanied by a tingling or burning sensation.
Swollen lymph nodes in the groin are another common finding, particularly during the first outbreak. These tender lumps are part of the body’s immune response and can help distinguish herpes from other causes of genital ulcers.
Why appearance alone isn’t enough
While these signs can be strong indicators, herpes isn’t always easy to spot. The virus has a way of mimicking other conditions. For example, syphilis, yeast infections, or even allergic reactions can present with similar redness or sores. And sometimes, symptoms are so mild they’re easily missed—just a bit of redness, or a vague itching sensation.
In very rare situations, HSV can show up in unexpected ways, like neurological symptoms that resemble a stroke or seizures. These atypical cases highlight just how unreliable appearance alone can be, especially when the virus moves beyond the skin.
The value of patient history
One of the most important diagnostic tools is the patient’s own story. A thorough sexual history helps doctors understand the likelihood of HSV exposure. Whether someone has had oral, vaginal, or anal sex, how many partners they’ve had, and whether any partners have known infections—all of this helps build a clearer picture.
Timing is another clue. Initial outbreaks usually appear within a few days to two weeks after exposure and are often more intense, while later recurrences tend to be shorter and milder. When this timeline matches a patient’s symptoms, it adds weight to the clinical impression.
Ultimately, while physical exams and visual signs can offer strong hints, it’s the combination of those signs with patient history and testing that leads to a confident and compassionate diagnosis. For anyone wondering how doctors test for herpes, it’s helpful to know that this first step—careful evaluation and listening—is just as important as any lab result.
Types of HSV Tests and How They Work
When someone asks, how do doctors test for herpes, the answer depends heavily on timing, symptoms, and available resources. There isn’t a one-size-fits-all approach—instead, doctors choose from several reliable testing options, each suited to different stages and presentations of the virus. These include swab-based tests for people with active symptoms and blood tests for those without visible signs.
Swab-Based Tests (Active Lesions Required)
Swab tests are the go-to option when a person has active sores or blisters. These tests directly detect the virus from the site of infection, offering a high degree of accuracy when lesions are present.
Polymerase Chain Reaction (PCR)
PCR is currently the most accurate and sensitive way to detect HSV. It works by identifying the DNA of the herpes virus in a sample taken from an active lesion. This allows for diagnosis even in early-stage infections, when symptoms may not be fully developed.
To collect the sample, a clinician uses a swab to gently gather fluid from a blister or ulcer. For PCR to be effective, the virus must be shedding at the time of testing—something that typically happens during an active outbreak. Compared to older methods, PCR is more reliable, especially in healing or recurrent lesions when other tests often miss the virus. Some PCR platforms show over 97% sensitivity, making them especially useful when accuracy matters most.
Importantly, PCR can differentiate between HSV-1 and HSV-2 with a high level of precision. This matters because the type of HSV influences how often someone might experience symptoms and what kind of follow-up care they may need.
Viral Culture
Before PCR became widely available, viral culture was considered the gold standard. This method involves placing the swab sample into a specialized medium where the virus can grow. If HSV is present, it replicates and creates visible effects in the lab-grown cells. Once the virus grows, additional testing can determine whether it’s HSV-1 or HSV-2.
While still used in some clinical settings—especially where PCR isn’t available—viral culture is far less sensitive. It often misses the virus in healing or recurrent sores, and results can take several days. Nonetheless, it remains a valuable option in certain research, legal, or neonatal cases.
Blood Tests (When No Lesions Are Present)
For people without active symptoms, blood tests can offer answers. These tests don’t look for the virus itself—they detect antibodies that the body produces in response to HSV infection.
Type-Specific Serologic Tests (IgG Antibody Tests)
IgG tests are the most reliable blood tests for identifying past HSV infection. They detect antibodies that form weeks after exposure and usually remain in the body for life. This makes them useful for people who suspect they’ve been exposed to herpes in the past—even if they’ve never noticed symptoms.
These tests can also differentiate between HSV-1 and HSV-2. They use specific viral proteins to trigger unique antibody responses, minimizing confusion with other viruses. For people who have partners with herpes, or who are pregnant and want to assess their risk, IgG testing offers crucial information. It can guide decisions about preventive care, like antiviral medication during pregnancy, and help inform open conversations between partners. Even for those who test negative, the process can lead to more thoughtful and protective sexual health behaviors.
Why IgM Tests Are Not Recommended
Although IgM tests are sometimes offered, they’re no longer recommended for herpes diagnosis. Unlike IgG, IgM antibodies can show up during both new and recurrent infections, making it hard to know whether the virus was recently acquired. These tests also have a high rate of false positives because IgM antibodies often cross-react with other viruses in the herpes family, like Epstein-Barr or varicella.
To make matters more confusing, some people don’t develop IgM at all during early infection, and many who do will also test positive for IgG at the same time. Without symptoms or a clear timeline, this makes the results difficult to interpret. Due to these issues, major health authorities like the CDC discourage the use of IgM testing and instead recommend type-specific IgG tests for accurate diagnosis.
Whether someone is dealing with a painful outbreak or simply looking for peace of mind, knowing how doctors test for herpes helps demystify the process. It also empowers individuals to ask informed questions and seek out the testing approach that fits their needs best.
When Doctors Choose Each Test
There’s no universal answer to how do doctors test for herpes—the choice of test depends on a person’s symptoms, timing, medical history, and risk factors. A thoughtful approach ensures not only the most accurate diagnosis but also the most supportive care plan going forward. Here’s how clinicians decide which test to use and when.
When symptoms are present: swab-based testing is preferred
If someone comes in during an active outbreak—with blisters, ulcers, or redness—the first step is usually a swab test, and PCR is the gold standard. PCR can detect even small amounts of viral DNA, making it much more sensitive than older methods like viral culture. It’s especially useful when lesions are healing or when outbreaks are mild and might otherwise be missed.
PCR also provides a clear distinction between HSV-1 and HSV-2. Knowing the type isn’t just a technical detail—it can help predict how often outbreaks might happen and shape conversations around managing the virus and preventing transmission to partners.
When there are no symptoms: blood tests offer insight
For people without visible symptoms—either because they’re asymptomatic or simply between outbreaks—blood tests, particularly type-specific IgG tests, are the go-to option. These tests detect antibodies that form after infection and can remain in the body for life.
This approach is especially valuable for people who have had a partner with herpes, or who suspect past exposure but never noticed any signs. However, it’s not immediate: antibodies can take up to six weeks to form after exposure. Testing too early can lead to false negatives, especially for HSV-1, which tends to be harder to detect with serologic tests. Despite this, IgG testing remains an essential tool for uncovering hidden infections and starting informed care.
During pregnancy: type-specific testing matters
Pregnancy presents a unique challenge. A primary HSV infection—especially in the third trimester—can pose a serious risk to the baby during delivery. Because many pregnant women may not show symptoms, type-specific IgG testing is often recommended as part of prenatal care.
If a pregnant person tests positive for HSV-2, doctors may recommend starting antiviral medication in the final weeks of pregnancy to reduce the chance of an outbreak during labor. In some cases, a cesarean delivery may be advised to protect the newborn from exposure during vaginal birth. These decisions rely on accurate diagnosis, which is why serologic testing plays such a key role in prenatal care.
For high-risk populations: routine testing can be protective
People who are at increased risk—such as those with HIV, individuals with multiple or new partners, or those with a history of other STIs—are strong candidates for HSV testing. HSV-2 is significantly more common among people living with HIV, and the two viruses can interact in ways that worsen outcomes. HSV-2 can increase both the risk of acquiring HIV and the rate at which HIV is shed, which may raise transmission risk.
In these cases, type-specific IgG testing offers more than just information—it can support behavior change, guide conversations about prevention, and help providers tailor treatment plans that reduce both symptoms and transmission.
In each scenario, the choice of test isn’t just about finding the virus—it’s about understanding the person, their needs, and the safest path forward. Whether symptoms are obvious or completely silent, knowing how doctors test for herpes can help people make sense of their options and take meaningful steps toward better health.
Timing Matters: When to Test and Retest
When it comes to diagnosing herpes, timing can make all the difference. Knowing how do doctors test for herpes is only part of the equation—understanding when to test is just as crucial. The accuracy of both swab-based and blood tests depends on where someone is in the course of infection, and misjudging that timing can lead to confusing or misleading results.
Swab testing: best within 48 hours of lesion appearance
Swab-based tests like PCR are most effective when performed early—ideally within the first 48 hours after sores appear. This is when the virus is actively shedding, and samples collected at this point have the highest chance of detecting HSV DNA. Waiting too long can reduce the test’s sensitivity, especially as lesions begin to heal and viral shedding slows.
PCR significantly outperforms viral culture in this critical window. While PCR can still detect low levels of virus in some healing sores, the likelihood of a false negative increases the longer someone waits. Lesions that are crusted or drying out often contain too little viral material to yield a positive result, even if HSV was the cause.
Blood testing: understanding the antibody timeline
If no symptoms are present, or if someone is trying to confirm past exposure, blood testing comes into play. But here too, timing matters. Type-specific IgG antibodies—what most herpes blood tests are looking for—don’t appear right away. It can take anywhere from 2 to 12 weeks after exposure for the body to produce enough antibodies to be detected.
For HSV-2, the average time to seroconversion (the point when antibodies become detectable) is around three to six weeks, depending on the test used. HSV-1 tends to be more unpredictable and may take even longer to trigger a detectable response. Some early results may come back with “low-positive” values, indicating a possible recent infection that hasn’t fully developed yet. In these cases, the best approach is often to wait a few weeks and test again.
Why early testing isn’t always conclusive
It’s understandable to want answers quickly, but testing too soon after potential exposure—especially with no visible symptoms—can lead to false reassurance. If someone is tested before their body has started producing antibodies or before sores have formed, both PCR and IgG tests might miss the infection.
For swab testing, doctors typically recommend waiting until lesions appear before collecting a sample. Testing too early, even with PCR, may not detect the virus if shedding hasn’t started yet. For blood tests, if initial IgG results are negative but there’s reason to believe exposure occurred, doctors often advise repeating the test around 12 weeks post-exposure to be confident in the result.
Follow-up testing can also clarify inconclusive results. If a test result falls into a “low-positive” or borderline range, retesting in two to four weeks can help confirm whether the infection is recent or if the earlier result was a false positive.
In short, getting tested for herpes isn’t just about the type of test—it’s about timing it right. Whether you’re managing an active outbreak or seeking answers after a possible exposure, knowing when to test and when to follow up can help ensure the results are as accurate and meaningful as possible.
What the Results Mean
After testing, many people find themselves holding a lab report and wondering what it truly means. Understanding the results—what they can tell you, what they can’t, and how they might shape your next steps—is just as important as the test itself. For anyone asking how do doctors test for herpes, it’s equally vital to know how doctors interpret what they find.
Positive vs. negative results: what they indicate
A positive IgG blood test result means that you’ve been exposed to herpes at some point. It doesn’t tell you when the infection happened or whether you’ll ever experience symptoms. Many people live with herpes for years without knowing, and a positive result can sometimes come as a surprise.
On the other hand, a negative result suggests no prior infection—but timing matters. If you were exposed recently, your body might not have developed detectable antibodies yet. Since it can take anywhere from two to twelve weeks for IgG antibodies to form, testing too early can lead to false negatives.
It’s also important to remember that test accuracy can vary, especially in populations where herpes is less common. In these cases, both false positives and false negatives can occur. That’s why, if a result is unclear or unexpected, doctors may recommend a confirmatory test like a Western blot for more definitive answers.
HSV-1 vs. HSV-2: why the type matters
Knowing which type of herpes you have—HSV-1 or HSV-2—can help guide treatment and conversations about risk. Genital HSV-1 infections, often acquired through oral-genital contact, tend to be milder and recur less often than HSV-2. HSV-2, by contrast, is more likely to reactivate and shed virus even when symptoms aren’t visible, increasing the likelihood of transmission.
In addition, HSV-2 has been linked to a higher risk of both acquiring and transmitting HIV. For people already living with HIV, co-infection with HSV-2 can complicate treatment and increase viral shedding. These factors make HSV typing an important part of understanding your health picture and planning ahead.
What a positive result doesn’t tell you
Despite their value, antibody tests like IgG have their limits. They can’t tell you where the infection is located—whether it’s oral or genital—and they can’t confirm whether the virus is currently active. Only a swab taken from a lesion during an outbreak can pinpoint the infection site.
Moreover, a positive IgG test doesn’t necessarily mean you’re contagious at the time of testing. Herpes is often transmitted during asymptomatic shedding, but that’s not something blood tests can detect. And in some cases, particularly with HSV-1, people with recurrent symptoms may still test negative due to the limitations of certain antibody tests.
Emotional and practical impact of a diagnosis
For many, receiving a herpes diagnosis brings an initial wave of distress. Feelings of shock, shame, guilt, or worry about relationships and self-image are common. But studies show that over time, these emotions often fade—especially with support, education, and honest conversations.
There’s no evidence that a herpes diagnosis leads to long-term psychological harm in most people. While concerns about dating and intimacy may linger at first, many people go on to have healthy relationships and satisfying sex lives. Counseling and education can be key to this adjustment, helping individuals understand the virus and communicate openly with partners.
As for behavior, the impact of a diagnosis varies. Some people take extra steps to protect their partners—using condoms more consistently, starting suppressive therapy, or being more open about their status. Others may need additional support to translate their diagnosis into practical changes. Either way, the goal is to empower, not shame, and to foster a deeper sense of agency over one’s health.
Getting tested is only one part of the process. Knowing how doctors test for herpes helps demystify the steps—but understanding the meaning behind the results is what brings clarity, compassion, and a path forward.
Next Steps After Diagnosis
Receiving a herpes diagnosis can feel overwhelming—but it doesn’t have to be the end of your confidence or peace of mind. Understanding what comes next empowers people to manage the condition effectively, communicate with partners honestly, and take meaningful steps toward well-being. Once the diagnosis is confirmed, here’s what often follows.
Starting treatment: episodic vs. suppressive therapy
One of the first decisions involves whether to treat herpes outbreaks as they occur or to take daily medication to keep the virus in check.
Episodic therapy is used at the first sign of symptoms—tingling, itching, or a new sore. Starting antiviral medication like acyclovir, valacyclovir, or famciclovir within 48 hours can reduce the severity and length of the outbreak. This approach works well for people who experience infrequent symptoms or prefer not to take daily medication.
Suppressive therapy, on the other hand, involves taking medication every day to reduce the number of outbreaks and lower the risk of passing the virus to others. This can be especially helpful for people with frequent or severe recurrences, or for those whose partners are not infected. While suppressive therapy significantly reduces viral shedding and transmission risk, it doesn’t eliminate it entirely—so ongoing precautions, like condom use, are still recommended.
Each person’s experience with herpes is different, so the choice between episodic and suppressive treatment depends on lifestyle, relationship dynamics, and personal comfort.
Telling your partner and supporting their health
Disclosing a herpes diagnosis to a partner can feel vulnerable, but it’s a key part of navigating relationships with honesty and care. Sharing this information gives partners a chance to make informed decisions and explore their own testing options.
Type-specific IgG testing is often recommended for sexual partners of people with herpes. Knowing whether a partner is already infected—or at risk—can help guide discussions about safer sex practices, suppressive therapy, or even whether the partner may want to begin taking preventive measures themselves.
Even with treatment, herpes can still be transmitted, especially during periods of asymptomatic shedding. That’s why disclosure, combined with consistent condom use and possibly daily antivirals, offers the best protection for both partners.
Questions to ask your healthcare provider
Having open conversations with your healthcare provider can make a big difference in how you manage herpes over time. Consider asking:
- What type of HSV do I have—HSV-1 or HSV-2?
- Is my infection more likely to be oral or genital?
- Should I use medication daily or only during outbreaks?
- How can I reduce the risk of passing it to others?
- Are there any side effects from long-term antiviral use?
- Can stress or lifestyle factors affect my outbreaks?
- Are there any counseling or support options available?
These questions can help you make informed choices, understand your condition more fully, and take ownership of your health.
Finding support and trusted information
You’re not alone in this. Many people find it helpful to connect with sexual health clinics, support groups, or online platforms that offer accurate information and emotional reassurance. Resources like the CDC’s Genital Herpes Fact Sheet or the American Sexual Health Association (ASHA) can be valuable starting points. Local clinics, including Planned Parenthood, also provide confidential counseling, testing, and treatment.
Emotional support matters, too. It’s common to feel anxiety or shame after a diagnosis, but these feelings often fade with time, especially when supported by good information and compassionate care. Counseling can help process the emotional weight of diagnosis and reduce the stigma that too often surrounds herpes. Most people go on to lead full, connected, and healthy lives—with herpes simply being one part of their story, not the whole of it.
Understanding Opens the Door to Peace of Mind
A herpes diagnosis—or even the question of one—can stir up a lot of uncertainty. But as this guide shows, getting tested is not just about labeling a condition; it’s about gaining clarity, reducing risk, and taking care of yourself and others. Whether you’re managing symptoms, supporting a partner, or simply trying to make informed decisions, knowing how doctors test for herpes helps replace fear with facts.
From swab tests to blood work, timing and context shape the accuracy and meaning of results. And no matter what those results reveal, there are effective treatments, trusted support systems, and empowering choices available. Herpes may be part of your health story—but it doesn’t define you.
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References
Amudha, V. P., Rashetha, Sucilathangam, G., Cinthujah, B., & Revathy, C. (2014). Serological Profile of HSV-2 in STD Patients: Evaluation of Diagnostic Utility of HSV-2 IgM and IgG Detection. Journal of clinical and diagnostic research : JCDR, 8(12), DC16–DC19.
Anaedobe, C. G., & Ajani, T. A. (2019). Co-infection of Herpes Simplex Virus Type 2 and HIV Infections among Pregnant Women in Ibadan, Nigeria. Journal of global infectious diseases, 11(1), 19–24.
Ashley-Morrow, R., Krantz, E., & Wald, A. (2003). Time course of seroconversion by HerpeSelect ELISA after acquisition of genital herpes simplex virus type 1 (HSV-1) or HSV-2. Sexually transmitted diseases, 30(4), 310–314.
Bhalla, P., & Patwardhan, V. (2013). Comparison of in-house PCR and direct fluorescent antibody assay for detection and typing of HSV. Sexually Transmitted Infections, 89, A359–A360.
Bobrow, M. (2016). Full Disclosure: Herpes Stigma and Communication Practices among HSV+ Individuals.
Brazg, J., & Gillett, B. (2015). A hair-raising diagnosis: goose bumps as sign of herpes simplex encephalitis. The American journal of emergency medicine, 33(5), 742.e1–742.e7422.
Choudhry, S., Ramachandran, V., Das, S., Bhattacharya, S., & Mogha, N. S. (2009). Serological profile of HSV-2 in patients attending STI clinic: evaluation of diagnostic utility of HSV-2 IgM detection. Indian Journal of Pathology & Microbiology, 52(3), 353–356.
Christensen, A., Haugsdal, M., & Bowdler, N. (2014). Importance of the physical exam and in-office tests in the evaluation of vulvovaginal irritation.
Crawford, K. H. D., Selke, S., Pepper, G., Goecker, E., Sobel, A., Wald, A., Johnston, C., & Greninger, A. (2024). Performance characteristics of highly automated HSV-1 and HSV-2 IgG testing. Journal of Clinical Microbiology, 62.
Crosby, R., Head, S., DiClemente, R., Meyerson, B., & Troutman, A. (2008). Do protective behaviors follow the experience of testing positive for HSV-2? Sexually Transmitted Diseases, 35, 787–790.
Cuyugan, M. G., Mulugeta, W., Thabolingam-Haridas, M., Wilson, T., Augenbraun, M., Elsassy, T., & Cerniglia, B. (2011). Knowledge of HSV-2 Serostatus in Asymptomatic Adults. Sexually Transmitted Infections, 87, A243.
Dabestani, N. M. (2016). Time Trends in First Episode Genital HSV Infections in an Urban STD Clinic.
Daniels, B., Wand, H., Ramjee, G., & MDP Team (2016). Prevalence of Herpes Simplex Virus 2 (HSV-2) infection and associated risk factors in a cohort of HIV negative women in Durban, South Africa. BMC research notes, 9(1), 510.
Dominguez, S. R., Pretty, K., Hengartner, R., & Robinson, C. C. (2018). Comparison of Herpes Simplex Virus PCR with Culture for Virus Detection in Multisource Surface Swab Specimens from Neonates. Journal of clinical microbiology, 56(10), e00632-18.
Duran, N. (2004). Serological Evaluation of HSV-1 and HSV-2 Infection in Pregnancy. Turkish Journal of Medical Sciences, 34, 97–101.
Duran, N., Yarkın, F., Evruke, C., & Koksal, F. (2004). Asymptomatic herpes simplex virus type 2 (HSV-2) infection among pregnant women in Turkey. The Indian Journal of Medical Research, 120(2), 106-110.
Engel, J. (2017). Suppressive antiviral medication should be counseled that they may still transmit HSV to their sexual partners.
Faron, M., Ledeboer, N., Patel, A. R., Beqa, S. H., Yen?Lieberman, B., Kohn, D., Leber, A., Mayne, D. J., Northern, W. I., & Buchan, B. (2016). Multicenter evaluation of Meridian Bioscience HSV 1&2 molecular assay for detection of herpes simplex virus 1 and 2 from clinical cutaneous and mucocutaneous specimens. Journal of Clinical Microbiology, 54, 2008-2013.
Gitman, M. R., Ferguson, D., & Landry, M. L. (2013). Comparison of Simplexa HSV 1 & 2 PCR with culture, immunofluorescence, and laboratory-developed TaqMan PCR for detection of herpes simplex virus in swab specimens. Journal of clinical microbiology, 51(11), 3765–3769.
Golden, M. R., Ashley-Morrow, R., Swenson, P., Hogrefe, W. R., Handsfield, H. H., & Wald, A. (2005). Herpes simplex virus type 2 (HSV-2) Western blot confirmatory testing among men testing positive for HSV-2 using the focus enzyme-linked immunosorbent assay in a sexually transmitted disease clinic. Sexually transmitted diseases, 32(12), 771–777.
Govindarajan, R., Morren, J., Malpe, C., & Salgado, E. (2012). Recurrent Herpes Simplex Type-2 Meningoencephalitis as a Stroke Mimicker. Neurology, 78.
Hatchette T. F. (2007). Herpes simplex virus type-specific serology: Where does it fit in the diagnostic armamentarium?. The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 18(4), 225–227.
Hires, L., Van Der Pol, B., Williams, J., Corey, L., Hook, E., Nye, M., Taylor, S., Martens, M., Mena, L., & Warren, T. (2011). Clinical evaluation of the BD HSV2 Qx assay for the direct qualitative testing of HSV2 as compared to viral culture and PCR. Sexually Transmitted Infections, 87.
Hook, E. (2016). A recommendation against serologic screening for genital herpes infection—What now? JAMA, 316(23), 2493–2494.
Koelle, D., & Wald, A. (2000). Herpes simplex virus: the importance of asymptomatic shedding. The Journal of Antimicrobial ChemotherapyKoelle, D. M., & Wald, A. (2000). Herpes simplex virus: the importance of asymptomatic shedding. The Journal of Antimicrobial Chemotherapy, 45(Suppl T3), 1–8.
LeGoff, J., Mayaud, P., Gresenguet, G., Weiss, H. A., Nzambi, K., Frost, E., Pepin, J., Belec, L., & ANRS 12-12 Study Group (2008). Performance of HerpeSelect and Kalon assays in detection of antibodies to herpes simplex virus type 2. Journal of clinical microbiology, 46(6), 1914–1918.
Liermann, K., Schäfler, A., Henke, A., & Sauerbrei, A. (2014). Evaluation of commercial herpes simplex virus IgG and IgM enzyme immunoassays. Journal of virological methods, 199, 29–34.
Mahmood, R., Mohamed, K., Saeed, N., Al-Banaa, K., Zimmerman, J., & Big, C. (2020). The vagaries of IgM: a case report of EBV infection with concomitantly false-positive IgM for CMV, VZV, and HSV. The Egyptian Journal of Internal Medicine, 32.
Marshall, D. L., Linfert, D. R., Draghi, A., McCarter, Y. S., & Tsongalis, G. J. (2001). Identification of herpes simplex virus genital infection: comparison of a multiplex PCR assay and traditional viral isolation techniques. Modern Pathology, 14, 152–156.
McGee, S. (2007). Evidence-Based Physical Diagnosis.
Mertz, G. (1990). Genital herpes simplex virus infections. The Medical Clinics of North America, 74(6), 1433–1454.
Morand P. (2002). Histoire naturelle de l’infection à herpès simplex de type 1 et 2. Excrétion virale asymptomatique. Transmission mère-enfant. Transmission indirecte [Natural history of HSV1 and HSV2 infection. Asymptomatic viral excretion. Mother-infant transmission. Indirect transmission]. Annales de dermatologie et de venereologie, 129(4 Pt 2), 577–585.
Nakubulwa, S., Mirembe, F. M., Kaye, D. K., & Kaddu-Mulindwa, D. (2009). Association between HSV-2 and HIV serostatus in pregnant women of known HIV serostatus attending Mulago hospital antenatal clinic, Kampala, Uganda. Journal of infection in developing countries, 3(10), 803–806.
Okonko, I. O., & Cookey, T. I. (2015). Seropositivity and determinants of immunoglobulin-G (IgG) antibodies against Herpes simplex virus (HSV) types -1 and -2 in pregnant women in Port Harcourt, Nigeria. African health sciences, 15(3), 737–747.
Page, J., Taylor, J., Tideman, R. L., Seifert, C., Marks, C., Cunningham, A., & Mindel, A. (2003). Is HSV serology useful for the management of first episode genital herpes?. Sexually transmitted infections, 79(4), 276–279.
Pantone, A., Van Der Pol, B., Williams, J., Corey, L., Hook, E., Body, B., Taylor, S., Fine, P., Ginde, S & Lebed, J. (2011). Clinical evaluation of the BD HSV1 Qx assay for the direct qualitative testing of HSV1 as compared to viral culture and PCR. Sexually Transmitted Infections, 87.
Patel, R., Stanberry, L., & Whitley, R. (2007). Review of recent HSV recurrent-infection treatment studies. Herpes: the journal of the IHMF, 14(1), 23-26.
Perre, P., & Nagot, N. (2012). Herpes simplex virus: a new era? The Lancet, 379, 598–599.
Provenzale, A., Evans, K., Russell, J., Hoory, T., & Mark, H. (2011). Psychosocial impact of a positive HSV-2 diagnosis on adults with unrecognized HSV-2 infection. Public Health Nursing, 28(4), 325-334.
Riedel, A., Bohnert, M., Scholz, C., Laengin, T., Melchior, W., Elke, E., & Gencay, M. (2013). Evaluation of Elecsys® immunoassay system for type-specific IgG antibodies to HSV-1 and HSV-2. Sexually Transmitted Infections, 89, A356–A357.
Roest, W., van Rooijen, M. V., Kwa, D., Jansen, G., & de Vries, H. D. (2013). False Negative HSV IgG1 and IgG2 Antibody Responses in Individuals with a Recurrent Genital Herpes Infection. Sexually Transmitted Infections, 89, A62.
Ross, K., Wald, A., & Johnston, C. (2011). HSV-2 serologic testing and psychosocial harm: a systematic review. Sexually Transmitted Infections, 87, A239–A240.
Sen, P., Sun, Y. J., Tan, H., Tan, S., & Chan, R. (2008). Comparison of nested-polymerase chain reaction and virus culture for the diagnosis of genital HSV infection. Singapore Medical Journal, 49(6), 466-469.
Seña, A., & Leone, P. (2012). Utility of episodic acyclovir therapy for HSV-2 in Africa. Sexually Transmitted Diseases, 39(1), 25–27
Shearer, L., Simmons, L., Mindel, A., Stanberry, L., & Rosenthal, S. (2012). Reducing the stigma of herpes simplex virus infection: lessons from an online video contest. Sexual Health, 9(5), 438–444.
Sheary, B., & Dayan, L. (2005). Herpes simplex virus serology in an asymptomatic patient. Australian Family Physician, 34(12), 1043–1046.
Shrivastava, S., Shrivastava, P., & Ramasamy, J. (2019). Rising trends of herpes simplex virus – 1: A global public health concern. Indian Journal of Sexually Transmitted Diseases and AIDS 40(1):77
Sicurella, M., Nicoli, F., Gallerani, E., Volpi, I., Berto, E., Finessi, V., Destro, F., Manservigi, R., Cafaro, A., Ensoli, B., Caputo, A., & Gavioli, R. (2014). An Attenuated Herpes Simplex Virus Type 1 (HSV1) Encoding the HIV-1 Tat Protein Protects Mice from a Deadly Mucosal HSV1 Challenge. PLoS ONE.
Slomka, M., Emery, L., Munday, P., Moulsdale, M., & Brown, D. (1998). A comparison of PCR with virus isolation and direct antigen detection for diagnosis and typing of genital herpes. Journal of Medical Virology.
Sun, Y., Chan, R. K., Tan, S. H., & Ng, P. P. (2003). Detection and genotyping of human herpes simplex viruses in cutaneous lesions of erythema multiforme by nested PCR. Journal of medical virology, 71(3), 423–428.
Tunbäck, P. (2004). Herpes simplex virus infection: Epidemiological aspects and analysis of the type-specific antibody response.
van Rooijen, M. S., Roest, W., Hansen, G., Kwa, D., & de Vries, H. J. (2016). False-negative type-specific glycoprotein G antibody responses in STI clinic patients with recurrent HSV-1 or HSV-2 DNA positive genital herpes, The Netherlands. Sexually transmitted infections, 92(4), 257–260.
Wald, A., & Ashley-Morrow, R. (2002). Serological testing for herpes simplex virus (HSV)-1 and HSV-2. Clinical Infectious Diseases, 35(Suppl 2), S173-S182.
Wong, A. A., Pabbaraju, K., Wong, S., & Tellier, R. (2016). Development of a multiplex real-time PCR for the simultaneous detection of herpes simplex and varicella zoster viruses in cerebrospinal fluid and lesion swab specimens. Journal of virological methods, 229, 16–23.
Young, S., Pol, B., Taylor, S., Fife, K., Hook, E., Patel, R., … & Lewinski, M. (2015a). Evaluation of the cobas® HSV 1 and 2 Test. Sexually Transmitted Infections, 91.
