Understanding the herpes outbreak timeline can make a real difference in how people manage the condition, both physically and emotionally. Many individuals first notice a strange tingle, a patch of itching skin, or a general sense of discomfort before anything visible appears. Recognizing these early signs isn’t just helpful—it can shorten the outbreak itself. That’s because beginning antiviral treatment during this early “prodrome” phase may lessen the severity and speed up healing.
But it’s not just about comfort. Herpes simplex virus (HSV) can spread even when no symptoms are present. This phenomenon, known as asymptomatic shedding, often occurs days before any blisters or sores show up. Understanding the rhythm and phases of an outbreak helps people better protect their partners and make informed decisions about intimacy and health.
It’s also important to know that the duration of symptoms isn’t the same for everyone or every outbreak. The first episode—when the body is encountering the virus for the first time—is usually the most intense. It may last up to two or three weeks, with more widespread sores and systemic symptoms like fever, swollen glands, and fatigue. Recurrent outbreaks, by contrast, are generally shorter—often resolving in a week or less—and tend to involve fewer symptoms overall. That’s because, by then, the immune system is primed to respond more efficiently.
There’s also a difference in how the two types of herpes—HSV-1 and HSV-2—behave over time. HSV-1, which traditionally causes oral herpes, is becoming a more common cause of genital infections, especially among younger individuals. While it can still cause painful outbreaks, it tends to recur less often and heal more quickly than HSV-2. HSV-2, on the other hand, is more likely to lead to repeated episodes and longer periods of viral shedding, even when no symptoms are present.
By understanding how herpes symptoms evolve over time—across both initial and recurrent episodes, and between different viral types—people can take more control of their care, reduce the risk of transmission, and feel less anxious about what’s to come.
The First Outbreak: What to Expect
A first herpes outbreak can feel overwhelming—not just physically, but emotionally too. Unlike recurrences, the initial episode tends to be longer and more intense because the body hasn’t built up any immunity to the virus yet. Most people with a primary infection can expect symptoms to last anywhere from two to four weeks, depending on factors like general health, immune function, and whether treatment is started early. For those experiencing their very first exposure to the virus (known as a primary infection), symptoms often land on the longer end of that range.
A Closer Look at the Timeline
Days 1–3: Early Sensations and Systemic Symptoms
It often starts subtly: a tingle, itch, or mild burning sensation in a localized area. This stage, known as the prodrome, is the body’s first response to viral activity. For many, this phase is also marked by flu-like symptoms—swollen lymph nodes, fatigue, and sometimes a low-grade fever. These are more common during the initial outbreak and tend to resolve within a few days.
Days 2–6: Lesions Appear
Blisters begin to form in clusters, usually around the genitals, anus, or nearby areas. These fluid-filled vesicles can be tender and are quick to rupture, leaving behind shallow ulcers that may be quite painful. This is often the phase when people realize they’re in the midst of a herpes outbreak.
Days 5–12: Peak Discomfort
This is typically the most intense stage of a primary outbreak. The lesions may multiply and spread, and systemic symptoms like fatigue or low-grade fever can persist. This is also the period when viral shedding is at its highest, which means the risk of transmission is greater—even if outward symptoms are beginning to fade.
Days 10–14: Beginning to Heal
Lesions begin to scab over and dry out. At this point, the worst is usually behind you, though it’s still possible for new sores to emerge. The body’s immune system becomes more active during this phase, helping to prevent further spread and start tissue repair.
Days 14–28: Recovery and Regeneration
By the third or fourth week, most lesions have healed, and the skin begins to return to normal. Scabs typically fall off without leaving scars, although some residual redness or irritation might linger for a few more days. Antiviral medications, if taken early, can shave several days off this timeline, easing pain and accelerating recovery.
Other Symptoms and How Long They Last
In addition to visible sores, a primary outbreak can bring a range of other symptoms:
- Fever and general malaise usually appear in the early phase and last around three to five days. In some cases, especially in younger adults, they may be accompanied by chills and muscle aches.
- Swollen lymph nodes, particularly in the groin or neck, tend to show up within the first few days and resolve within a week.
- Fatigue may linger slightly longer. While it often fades within five days, some people—especially those with preexisting immune sensitivities—may experience tiredness well into the recovery period.
Another commonly reported issue is pain during urination, which can last up to 10 days. This discomfort often stems from ulceration near the urethra. In women, sores on or near the labia can make urination especially painful, while men may experience similar discomfort from periurethral lesions. Again, antiviral medications can ease these symptoms and help shorten the overall course of the outbreak.
While the herpes outbreak timeline for a first episode can seem long and difficult, it’s important to remember that recurrences are typically much shorter and milder. Knowing what to expect from this initial episode can provide some peace of mind—and help people feel more in control of their health.
Recurrent Outbreaks: A Shorter Timeline
For most people living with herpes, the first outbreak is the hardest. After that, the body becomes better equipped to handle the virus, and future episodes tend to be far less intense. Recurrent outbreaks usually follow a much shorter and more manageable pattern, often resolving in 7 to 10 days—sometimes even faster. This quicker recovery is largely thanks to the immune system’s memory, which helps it respond more efficiently the second time around.
Shorter, Milder, and More Predictable
Compared to the widespread discomfort and systemic symptoms of a primary outbreak, recurrent episodes are often quite limited. Lesions tend to be fewer, smaller, and more localized—often appearing on just one side of the body. The pain is usually less severe, and in many cases, there are no accompanying symptoms like fever or swollen glands. Instead, people might experience mild itching or tingling, which may come and go in a day or two.
These familiar early signs—known as prodromal symptoms—give many people a helpful window to act. Starting antiviral treatment during this phase can make a big difference, sometimes preventing sores from developing altogether or shortening the outbreak by several days.
Antiviral medications like acyclovir or famciclovir can be especially effective when used early. Even a one-day course has been shown to reduce symptom severity and healing time. Over time, with or without suppressive therapy, many individuals find their outbreaks become less frequent and easier to manage. The virus doesn’t go away, but the body gets better at keeping it in check.
Another aspect of the herpes outbreak timeline that changes with recurrence is that not all episodes are visible. Some people experience what’s called an “aborted” outbreak, where they feel tingling or discomfort but no blisters ever form. Others might not feel anything at all. These silent recurrences still involve viral shedding, meaning the virus can be passed to others even when symptoms are absent. This is especially common with HSV-2.
Faster from Start to Finish
One of the most notable features of recurrent outbreaks is how quickly they progress. Prodromal sensations like tingling or mild burning may last only a few hours—far shorter than during a primary infection. If blisters do appear, they often begin healing within a day or two, especially if treatment is started right away. In some cases, antiviral medications taken at the first hint of symptoms can stop the outbreak in its tracks.
This rapid healing isn’t just due to medication—it’s also a sign of the immune system’s growing efficiency. With each recurrence, the body’s response becomes more targeted, often suppressing the virus before it can cause noticeable damage.
Interestingly, some outbreaks may skip the blister stage entirely. Individuals might experience a few hours of discomfort or irritation, only to have it pass without visible signs. These episodes still reflect active viral behavior, even if they’re not outwardly apparent.
Over time, many people notice a clear pattern in their own outbreaks—both in terms of timing and triggers. Recognizing these patterns can be empowering, making it easier to manage symptoms and reduce the risk of passing the virus to others.
Factors That Can Affect Symptom Duration
While the herpes outbreak timeline tends to follow a familiar pattern, not everyone experiences it the same way. Several factors can influence how long symptoms last and how intense they become—from the strength of a person’s immune system to the timing of treatment and the type of outbreak they’re experiencing.
The Role of the Immune System
One of the most important influences on outbreak duration is the health of the immune system. People with strong immune defenses are generally able to contain the virus more quickly, leading to shorter and milder episodes. The body’s first line of defense includes type I interferons—proteins that help block viral replication early in an infection. When these signals function well, they can dramatically limit how far the virus spreads and how long symptoms persist.
On the other hand, people with weakened immunity—whether due to stress, illness, or underlying medical conditions—may experience longer or more severe outbreaks. Genetic differences also come into play. Some individuals naturally mount a more efficient immune response than others, which can explain why herpes symptoms vary so widely from person to person.
Why Timing Matters with Treatment
Another key factor is how soon antiviral treatment is started. The earlier medication like acyclovir or valacyclovir is taken—ideally during the prodrome stage—the more effective it tends to be. Early intervention can reduce the duration of an outbreak by up to two days and may even prevent blisters from forming at all.
Delaying treatment, particularly during a first outbreak, often leads to longer healing times and more discomfort. Once lesions have fully developed, antivirals can still help, but they’re less likely to prevent the more painful aspects of the episode.
Oral vs. Genital Outbreaks
Where the outbreak occurs also makes a difference. Oral herpes, typically caused by HSV-1, tends to be shorter and less severe. The tissue around the mouth is different from genital tissue, and outbreaks in this area often resolve in about 5 to 8 days.
In contrast, genital herpes—especially when caused by HSV-2—tends to be more persistent. Outbreaks can last 7 to 10 days on average and are often accompanied by longer periods of viral shedding, even after visible symptoms have healed.
The Impact of Suppressive Therapy and Self-Care
For those who experience frequent recurrences, suppressive antiviral therapy can make a significant difference. Taking medication daily helps reduce both the number and severity of outbreaks. It can also lower the chances of transmitting the virus to others, though it doesn’t eliminate the risk entirely.
In addition to medication, self-care plays an important role in recovery. Simple strategies—like staying hydrated, managing stress, getting enough rest, and keeping the affected area clean and dry—can help the body heal more quickly. Avoiding known triggers, such as friction, certain foods, or emotional stressors, can also reduce the likelihood of an outbreak starting in the first place.
Ultimately, each person’s experience with herpes is shaped by a combination of biology, behavior, and treatment. Understanding these factors gives people more tools to manage their symptoms and reduce the impact of outbreaks on daily life.
Healing Without Treatment: What to Know
While antiviral medications can speed recovery and reduce the intensity of symptoms, it’s important to know that herpes outbreaks can heal on their own. For many people, especially those with mild or infrequent episodes, the body is capable of resolving symptoms without medical intervention. The herpes outbreak timeline may be a little longer without treatment, but healing still follows a natural, predictable path.
The Body Knows What to Do
Most herpes simplex virus (HSV) outbreaks are self-limiting. That means the immune system will eventually clear the active lesions, typically within 7 to 14 days. This process is driven by the body’s innate defenses—particularly the release of cytokines and the action of T-cells, which work to control viral replication and begin tissue repair. Even without antiviral drugs, the immune response plays a powerful role in reducing viral activity and supporting healing.
However, when no treatment is used, symptoms may last longer. Lesions can take a few extra days to crust over and may remain uncomfortable throughout the full course of the outbreak. People are also more likely to experience the full progression of symptoms—from the first signs of tingling to fully developed sores—than they would if treatment had been started early.
When Healing Takes Longer
There are some potential downsides to letting an outbreak run its course without support. Open lesions, especially in sensitive areas like the genitals or mouth, can be vulnerable to secondary infections. Bacterial superinfections can slow healing and increase the chance of scarring—particularly if hygiene is poor or the person is immunocompromised.
Without antivirals to speed things along, pain and discomfort may persist longer too. Lesions that heal more slowly, particularly in friction-prone areas, can remain tender and disruptive to daily life. And for people with weakened immune systems, the risks are higher: outbreaks can linger for weeks, and the chance of complications increases significantly.
Supporting the Healing Process
Even when choosing not to use antiviral medications, there are steps that can make a real difference in recovery. Pain relief matters—not just for comfort, but also to support gentle, uninterrupted healing. Soothing topical treatments like lidocaine, aloe vera, or calming natural creams can reduce irritation and help protect the skin as it repairs.
Hygiene is equally important. Washing hands before and after touching the affected area, keeping the skin clean and dry, and avoiding friction or trauma all reduce the risk of further irritation or infection. These simple actions also help prevent the virus from spreading to other parts of the body or to other people.
Protecting lesions from friction—whether that means avoiding tight clothing, using protective dressings, or modifying activity—is crucial. Disrupted sores take longer to heal and are more likely to cause lingering symptoms.
Healing without treatment is possible, and for some, it’s a preferred approach. But it’s important to be aware of the trade-offs and to support the body as best as possible throughout the outbreak.
When Symptoms Linger: What’s Normal vs. What’s Not
For most people, a herpes outbreak follows a relatively predictable pattern—symptoms emerge, peak, and then begin to heal within a week or two. But sometimes, things don’t go quite as expected. If symptoms stretch beyond the typical herpes outbreak timeline, it’s worth paying attention. While longer healing doesn’t always mean something is seriously wrong, there are situations where it may signal complications or the need for medical care.
What Might Signal a Problem
In general, herpes lesions should start to improve within 7 to 10 days, and most will heal completely within two weeks. When healing takes longer—especially if there’s no noticeable progress after two to three weeks—it may be a sign of something more complex. For example, a resistant strain of the virus or a secondary bacterial infection could be slowing the process.
Lesion appearance can also offer clues. In healthy individuals, outbreaks tend to be localized and consistent in shape. But in people with compromised immune systems, herpes can sometimes appear in more unusual ways—deeper, linear ulcers, or widespread patches of lesions across the body. Known as the “knife-cut sign,” these patterns often indicate that the virus is behaving differently and may need more aggressive treatment.
Another red flag is persistent pain, burning, or neurological sensations such as tingling or numbness that continue long after visible sores have healed—or even occur without any visible outbreak at all. These symptoms can suggest nerve involvement, which sometimes happens with HSV, especially if it spreads to nearby nerve roots or, in rare cases, affects the brain or spinal cord.
When to Seek Medical Advice
It’s a good idea to reach out to a healthcare provider if:
- Lesions aren’t healing or are getting worse after 10 days
- Pain or discomfort persists even after the skin looks healed
- Symptoms are unusually severe or widespread
- Lesions appear in uncommon areas, like the arms, back, or thighs
- You have a weakened immune system, such as from HIV, cancer treatment, or organ transplantation
In people with immune suppression, even a mild HSV outbreak can escalate quickly and last significantly longer. Prompt medical attention can help prevent complications and ensure the right treatment is used.
What Can Cause Longer Outbreaks?
Several factors may explain why a herpes outbreak is lingering beyond the usual timeline. One major cause is immunosuppression. People with weakened immune defenses may struggle to control the virus, allowing symptoms to last longer and potentially become more severe.
Another possibility is antiviral resistance. This is rare but more likely in individuals who’ve used long-term antiviral therapy or have immune compromise. In these cases, standard treatments like acyclovir may no longer work effectively, and other medications—such as foscarnet or cidofovir—might be needed.
Sometimes, incomplete or delayed treatment can also prolong symptoms. Starting antivirals too late, not taking them consistently, or receiving a dose that’s too low may reduce the medication’s effectiveness. Ensuring timely and appropriate treatment is crucial to minimizing outbreak duration and discomfort.
Understanding what’s typical—and what’s not—within the herpes outbreak timeline helps people make informed decisions about their care. Knowing when to seek help ensures that symptoms are properly managed and that any underlying issues are addressed early.
Timeline of Contagiousness
Understanding when herpes is most likely to spread is just as important as knowing how symptoms unfold. The herpes outbreak timeline doesn’t just guide healing—it also helps people make safer, more informed choices about intimacy and contact during and after an outbreak. One of the more complicated aspects of herpes is that the virus can be contagious even when symptoms aren’t visible.
When Is the Virus Most Contagious?
The highest risk of transmission occurs during active outbreaks, especially when lesions are open and fluid-filled. This is when the virus is most concentrated on the surface of the skin. Vesicles and ulcers release high amounts of viral particles, making this phase the most infectious.
But shedding can begin before symptoms appear—sometimes up to 48 hours earlier—and can continue after visible healing has started. Even when a sore looks like it’s almost gone, viral activity may still be happening beneath the surface.
Contagiousness is also higher in the first year after infection. During this period, the body is still learning how to respond to the virus, which results in more frequent shedding and a greater chance of passing it to others.
Shedding Without Symptoms
Perhaps one of the most challenging aspects of herpes is asymptomatic shedding. This means the virus is present on the skin and capable of spreading, but there are no noticeable symptoms at all. In fact, studies suggest that the majority of HSV-2 transmissions—up to 70–80%—occur during times when no sores are visible.
How often this happens varies by person and by virus type. People with HSV-2 shed the virus asymptomatically on about 10 to 20% of days, while those with genital HSV-1 shed less frequently—roughly 3 to 7% of days—and tend to see a quicker decline in shedding over time.
It’s also possible for someone who has never had noticeable symptoms to still carry and shed the virus. This is known as subclinical shedding, and while it may be harder to detect, it can still lead to transmission.
Resuming Intimacy After an Outbreak
Knowing when it’s safe to be physically intimate again can be tricky. The general recommendation is to wait until all sores have completely healed—meaning the skin is no longer broken, there’s no scabbing, and no tenderness remains. This usually occurs around 7 to 10 days after the start of an outbreak.
Even then, because shedding can continue for several days after healing, some healthcare providers recommend waiting an additional 3 to 5 days before resuming sexual activity—particularly with new or uninfected partners.
Using condoms and daily suppressive antiviral therapy can further reduce the risk of transmission. While these methods don’t eliminate risk altogether, they significantly lower the chances of both symptomatic and asymptomatic shedding. Suppressive therapy with medications like valacyclovir can cut down on asymptomatic shedding by up to 50%, making it a helpful option for many people.
Understanding the contagious phases of the herpes outbreak timeline helps not only with prevention but also with reducing stress and uncertainty. By learning how the virus behaves—even when it’s invisible—people can make more empowered and respectful choices in their relationships and health routines.
Tips to Support Faster Recovery
While the body can often manage a herpes outbreak on its own, certain strategies can help speed up healing, reduce discomfort, and lessen the impact of symptoms. Whether it’s your first episode or a familiar recurrence, these supportive approaches can make a noticeable difference in how quickly things resolve—and how you feel along the way.
Start Antivirals Early When Possible
One of the most effective ways to shorten the herpes outbreak timeline is by taking antiviral medication early. Drugs like acyclovir, valacyclovir, and famciclovir work by interfering with the virus’s ability to replicate. When started within the first 48 hours of symptoms—ideally during the prodrome phase—they can significantly reduce the size and duration of lesions, as well as overall discomfort.
Topical antivirals may also be useful, especially for smaller or less severe outbreaks. Penciclovir cream, for example, has been shown to help speed healing even when applied after lesions appear. Combination creams, such as those that include acyclovir and hydrocortisone, can be particularly effective by reducing both viral activity and inflammation.
Soothe and Support the Skin
Alongside medication, topical care and gentle relief measures can play an important role in recovery. Cooling compresses—simple cloths soaked in cold water and applied to the skin—can help ease swelling, reduce pain, and bring a sense of relief. While they don’t directly fight the virus, they can reduce inflammation and make the healing process more comfortable.
Natural products may also provide support. Lavender cream, for instance, has shown promise in reducing pain, lesion size, and healing time thanks to its antiviral and anti-inflammatory properties. Over-the-counter options like docosanol (sold as Abreva®) work by preventing the virus from entering healthy cells, which can limit the spread and severity of an outbreak when used early.
Strengthen Recovery from the Inside Out
Lifestyle choices have a real impact on how the body handles outbreaks. Getting adequate rest and managing stress levels can improve immune function, making it easier to control symptoms and heal faster. Techniques like mindfulness, breathing exercises, or yoga can help calm the nervous system and reduce the likelihood of stress-triggered recurrences.
Nutrition also plays a role in skin healing. While the evidence is still emerging, some people find that diets rich in vitamin C, zinc, and lysine support recovery and reduce outbreak frequency. Staying well hydrated helps the body repair tissue and maintain resilience against further irritation.
Finally, avoiding known triggers can help shorten and even prevent outbreaks. Common culprits include UV exposure, friction or trauma to affected areas, and surgical or dental procedures. Wearing sunscreen on the lips, using protective lip balm, and taking preventive antivirals before known triggers may reduce the risk of flare-ups.
Together, these strategies offer a practical toolkit for managing outbreaks more effectively and gently. Whether you choose prescription treatment, natural remedies, or a combination of both, small steps can lead to meaningful relief.
Understanding Your Body, One Outbreak at a Time
Living with herpes can feel isolating at first, but understanding the rhythms of your body—the herpes outbreak timeline, the early signs, the healing process—can turn uncertainty into empowerment. Every person’s experience is different, and there’s no single “right” way to manage symptoms. What matters most is knowing that healing is possible, and that you have options—whether through medication, lifestyle support, or simply learning when to rest and care for yourself.
Outbreaks don’t define you. They’re just one part of a broader picture—of health, of resilience, of learning how to listen to your body with greater care and compassion. Over time, many people find that managing herpes becomes a small, manageable part of life, not something that overshadows it.
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References
Altaei, T. S., & Ahmed, S. (2012). Topical treatment of herpes simplex lesion by lavender cream. Journal of Baghdad College of Dentistry, 24.
Andersen-Nissen, E., Chang, J. T., Thomas, K. K., Adams, D., Celum, C., Sanchez, J., Coombs, R. W., McElrath, M. J., & Baeten, J. M. (2016). Herpes Simplex Virus Suppressive Therapy in Herpes Simplex Virus-2/Human Immunodeficiency Virus-1 Coinfected Women Is Associated With Reduced Systemic CXCL10 But Not Genital Cytokines. Sexually transmitted diseases, 43(12), 761–764.
Bader, C., Crumpacker, C. S., Schnipper, L. E., Ransil, B., Clark, J. E., Arndt, K., & Freedberg, I. M. (1978). The natural history of recurrent facial-oral infection with herpes simplex virus. The Journal of infectious diseases, 138(6), 897–905.
Baldwin, K. J., & Cummings, C. L. (2018). Herpesvirus Infections of the Nervous System. Continuum (Minneapolis, Minn.), 24(5, Neuroinfectious Disease), 1349–1369.
Beauman, J. G. (2005). Genital herpes: a review. American Family Physician, 72(8), 1527–1534.
Bella, S. D., Taglietti, F., & Petrosillo, N. (2015). Painful lesions in an HIV-1 seropositive African woman. Journal of Clinical Research, 2, 28.
Bello-Silva, M. S., de Freitas, P. M., Aranha, A. C., Lage-Marques, J. L., Simões, A., & de Paula Eduardo, C. (2010). Low- and high-intensity lasers in the treatment of herpes simplex virus 1 infection. Photomedicine and laser surgery, 28(1), 135–139.
Bieńkowski, K., Bielaska, A., Wesołek-Bielaska, E., Kołodziej, W., Gałązka, J.K., & Greszta, M. (2024). Chronic fatigue syndrome related to herpes simplex viruses infection – a narrative review. Quality in Sport.
Burgers, D. C., Pompe, J., Kovacs, I., & Sturm, P. (2015). Widespread HSV-1 infection in ICU patient with respiratory failure.
Chan, T. T., Barra, N., Lee, A. J., & Ashkar, A. (2011). Innate and adaptive immunity against herpes simplex virus type 2 in the genital mucosa. Journal of Reproductive Immunology, 88(2), 210–218.
Chemaly, R. F., Shafat, T., Wald, A., Kotton, C. N., Papanicolaou, G., Yong, M. K., Miller, V., Komatsu, T. E., Mullick, C., Hodowanec, A. C., Westman, G., Khawaja, F., Birkmann, A., & Ljungman, P. (2025). Refractory and Resistant Herpes Simplex Virus Mucocutaneous Infections in Immunocompromised Patients: Literature Review and Proposed Definitions for Use in Clinical Trials. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ciae638. Advance online publication.
Cole, S. (2020). Herpes Simplex Virus: Epidemiology, Diagnosis, and Treatment. The Nursing Clinics of North America, 55(3), 337–345.
Corey, L., Adams, H. G., Brown, Z. A., & Holmes, K. K. (1983). Genital herpes simplex virus infections: Clinical manifestations, course, and complications. Annals of Internal Medicine, 98(6), 958-972.
Corey, L., Reeves, W., & Holmes, K. (1978). Cellular immune response in genital herpes simplex virus infection. The New England Journal of Medicine.
Coyle, P. V., O’Neill, H. J., Wyatt, D. E., McCaughey, C., Quah, S., & McBride, M. O. (2003). Emergence of herpes simplex type 1 as the main cause of recurrent genital ulcerative disease in women in Northern Ireland. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 27(1), 22–29.
Croll, B. J., Dillon, Z. M., Weaver, K., & Greenberg, M. (2017). Subtle presentation of herpes simplex encephalitis. The American Journal of Emergency Medicine, 35(1), 200.e1–200.e2.
Dhar, J., Carey, P., & Alawattegama, A. (1992). Atypical presentations of herpes simplex virus infection. International Journal of STD & AIDS, 3(6), 442–444.
Eduardo, C., Bezinelli, L., Eduardo, F., Lopes, R., Ramalho, K. M., BeLLO-siLva, M., & Esteves-Oliveira, M. (2012). Prevention of recurrent herpes labialis outbreaks through low-intensity laser therapy. Lasers in Medical Science, 27, 1077–1083.
Epstein, J., Gharapetian, S., Rejali, A., Zabner, R., Lill, M., & Tzachanis, D. (2016). Management of resistant oral HSV following HSCT. Supportive Care in Cancer, 24, 3603–3606.
Esmann J. (2001). The many challenges of facial herpes simplex virus infection. The Journal of antimicrobial chemotherapy, 47 Suppl T1, 17–27.
Fife, K. (2018). Herpes therapy enters the molecular age. The Journal of Infectious Diseases, 218(11), 1689–1690.
Gilbert, S., Corey, L., Cunningham, A., Malkin, J., Stanberry, L., Whitley, R., & Spruance, S. (2007). An update on short-course intermittent and prevention therapies for herpes labialis. Herpes, 14 Suppl 1, 13A–18A.
Graham, J. B., Swarts, J., Mooney, M., & Lund, J. M. (2022). Immunogenetic determinants of HSV-2 infection and disease. The Journal of Immunology.
Griffiths, P. (2004). Interrupting transmission of genital herpes. Reviews in Medical Virology, 14.
Groves, M. J. (2016). Genital herpes: A review. American Family Physician, 93(11), 928-934.
Hsieh, W. B., Chiu, N. C., Hu, K. C., Ho, C. S., & Huang, F. Y. (2007). Outcome of herpes simplex encephalitis in children. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 40(1), 34–38.
Hull, C., & Brunton, S. (2010). The role of topical 5% acyclovir and 1% hydrocortisone cream (Xerese™) in the treatment of recurrent herpes simplex labialis. Postgraduate Medicine, 122(5), 1–6.
Indra, G., Maragathavalli, G., & Rajendran, D. (2020). Analysis of various treatment modalities of herpetic lesions. International Journal of Research in Pharmaceutical Sciences, 11, 1830–1836.
Kuhls, T., Sacher, J., Pineda, E., Santomauro, D., Wiesmeier, E., Growdon, W., & Bryson, Y. (1986). Suppression of recurrent genital herpes simplex virus infection with recombinant ?2 interferon. The Journal of Infectious Diseases.
Kuo, J. Y., Yeh, C. S., Wang, S. M., Chen, S. H., Wang, J. R., Chen, T. Y., & Tsai, H. P. (2023). Acyclovir-resistant HSV-1 isolates among immunocompromised patients in southern Taiwan: Low prevalence and novel mutations. Journal of medical virology, 95(8), e28985.
LeBoeuf, N. R., Lieb, J., & Grossman, M. (2010). Linear erosive HSV: The ‘knife‐cut sign’ in corticosteroid-treated patient. Clinical and Experimental Dermatology, 35.
Leone, P. (2005). Reducing the risk of transmitting genital herpes: advances in understanding and therapy. Current Medical Research and Opinion, 21, 1577–1582.
Leung, D. T., & Sacks, S. L. (2004). Docosanol: a topical antiviral for herpes labialis. Expert opinion on pharmacotherapy, 5(12), 2567–2571.
Marcu, D., Chele, N., & Motelica, G. (2024). Characteristics of recurrent chronic herpetic stomatitis. Journal of Stomatological Medicine.
Marlina, E., & Soebadi, B. (2013). Management of recurrent oral herpes simplex infection. Journal of Dentomaxillofacial Science, 12, 28.
Meads, D., McKenna, S., Bonney, M., & Bloch, M. (2009). Further validation and responsiveness assessment of the Herpes Outbreak Impact Questionnaire and Herpes Symptom Checklist. Value in Health, 12(2), 397–400.
Melvin, A. J., Mohan, K. M., Vora, S. B., Selke, S., Sullivan, E., & Wald, A. (2022). Neonatal Herpes Simplex Virus Infection: Epidemiology and Outcomes in the Modern Era. Journal of the Pediatric Infectious Diseases Society, 11(3), 94–101.
Mertz, G. J., Benedetti, J., Ashley, R., Selke, S. A., & Corey, L. (1992). Risk factors for the sexual transmission of genital herpes. Annals of internal medicine, 116(3), 197–202.
Nilsen, A. E., Aasen, T., Halsos, A. M., Kinge, B. R., Tjøtta, E. A., Wikström, K., & Fiddian, A. P. (1982). Efficacy of oral acyclovir in the treatment of initial and recurrent genital herpes. Lancet (London, England), 2(8298), 571–573.
Patel R. (2008). Making the most of episodic antiviral therapy for genital herpes. Sexual health, 5(3), 213–214.
Peacock, J.E., Kaplowitz, L.G., Sparling, P.F., Durack, D., Gnann, J., Whitley, R.J., Lovett, M., Bryson, Y., Klein, R.J., Friedman-kien, A.E., Knowlton, G.M., & Davis, L.G. (1988). Intravenous acyclovir therapy of first episodes of genital herpes: a multicenter double-blind, placebo-controlled trial. The American journal of medicine, 85 3, 301-6 .
Piperi, E., Papadopoulou, E., Georgaki, M., Dovrat, S., Bar Illan, M., Nikitakis, N. G., & Yarom, N. (2024). Management of oral herpes simplex virus infections: The problem of resistance. A narrative review. Oral diseases, 30(3), 877–894.
Pol, B., Daniel, G., Aaron, K. J., Cooper, C. K., Kodsi, S., & Paradis, S. (2017). Decline in genital shedding in the year after first clinical episode genital herpes simplex virus type 1. Sexually Transmitted Infections, 93, A24.
Raborn, G. W., & Grace, M. (2003). Recurrent herpes simplex labialis: Selected therapeutic options. Journal, 69(8), 498–503.
Reynolds, S. (2009). Role of HSV-2 suppressive therapy for HIV prevention. Future Microbiology, 4(9), 1095-1097.
Schiffer, J. T., Mayer, B. T., Fong, Y., Swan, D. A., & Wald, A. (2014). Herpes simplex virus-2 transmission probability estimates based on quantity of viral shedding. Journal of the Royal Society, Interface, 11(95), 20140160.
Schiffer, J., Abu-Raddad, L., Mark, K., Zhu, J., Selke, S., Magaret, A., Wald, A., & Corey, L. (2009). Frequent release of low amounts of herpes simplex virus from neurons: Results of a mathematical model. Science Translational Medicine, 1, 7ra16.
Schindl, A., & Neumann, R. (1999). Low-intensity laser therapy is an effective treatment for recurrent herpes simplex infection. Results from a randomized double-blind placebo-controlled study. The Journal of investigative dermatology, 113(2), 221–223.
Schmid-Wendtner, M. H., & Korting, H. C. (2004). Penciclovir cream–improved topical treatment for herpes simplex infections. Skin pharmacology and physiology, 17(5), 214–218.
Siegel M. A. (2002). Diagnosis and management of recurrent herpes simplex infections. Journal of the American Dental Association (1939), 133(9), 1245–1249.
Slomka, M., Emery, L., Munday, P., Moulsdale, M., & Brown, D. (1998). A comparison of PCR with virus isolation and direct antigen detection for diagnosis and typing of genital herpes. Journal of Medical Virology.
Tang, I. T., & Shepp, D. (1992). HSV infections in cancer patients: Prevention and treatment. Oncology, 6(7), 101–110.
Tarchini, G. (2010). Asymptomatic herpes simplex virus type 2 shedding—potential pitfalls of broader testing and aggressive suppression. The Journal of Infectious Diseases, 202(6), 979.
Tyring, S., Richwald, G., & Hamed, K. (2007). Single-day therapy: an expert opinion on a recent development for the episodic treatment of recurrent genital herpes. Archives of gynecology and obstetrics, 275(1), 1–3.
Webb, D., & Fife, K. (1987). Genital herpes simplex virus infections. Infectious Disease Clinics of North America, 1(1), 97–122.
Whitley, R., & Hook, E. (2022). Shedding Patterns of Genital Herpes Simplex Virus Infections. JAMA.
Wicaksono, I. K., Ridho, F., & Zakiawati, D. (2024). Atypical Clinical Manifestations of Herpes Simplex Virus-1 Infection. International medical case reports journal, 17, 933–937.
Zhang, M., Liu, Y., Wang, P., Guan, X., He, S., Luo, S., Li, C., Hu, K., Jin, W., Du, T., Yan, Y., Zhang, Z., Zheng, Z., Wang, H., & Hu, Q. (2015). HSV-2 immediate-early protein US1 inhibits IFN-β production by suppressing association of IRF-3 with IFN-β promoter. Journal of immunology (Baltimore, Md. : 1950), 194(7), 3102–3115.